Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood poor response rates and high costs associated with treatment mandate the search for new therapies. Rheumatoid arthritis is a long term inflammatory condition that can affect the joints and other tissues and organs in the body what causes rheumatoid arthritis rheumatoid arthritis ra is considered an autoimmune condition which means it is caused by your immune system making antibodies which attack your tissue. A major challenge in human genetics is to devise a systematic strategy to integrate disease associated variants with diverse genomic and biological datasets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis ra 1here we performed a genome wide association study gwas meta analysis in a total of 100000 subjects of . Rheumatoid arthritis ra is a multifactorial chronic inflammatory disease affecting primarily the joints with prevalence of between 05 1 pain fatigue and disability which may be considered as stress factors are common challenges that may subsequently lead to psychological distress depression commonly co occurs with ra in the range of 13 to 20 and above based on . Rheumatoid arthritis 1st edition by marc c hochberg alan j silman josef s smolen michael e weinblatt and michael h weisman this state of the art reference provides current insights into the etiology diagnosis and management of rheumatoid arthritis
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